"Immunopharmacology of Mast Cells and Basophils -The Handbook of Immunopharmacology-(HC)"
John C. Foreman (ed.)/Academic Press
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- 1. "Introduction to Mast Cells and Basophils"(John C. Foewman)
- 2. "Development of Mast Cells and Basophils"
(Yukihiko Kitamura, Tsutomu Kasugai, Shintaro Nomura and Hiroshi Matsuda)
- 1) Introduction
- 2) Development of Mast Cells
- ・Useful Mutant Animals
- ・Culture of Mast Cells
- ・Differenciation Process
- ・Regulation of Developmant
- ・Effect of Microenvironment on Phenotypes
- ・Inhabition of Development
- 3) Development of Basophils
- ・Differentiation Process
- ・Regukation of Development
- 4) Concluding Remarks
- 5) Acknowledements
- 6) References
- 3. "Mast Cells Heterogeneity"(Kim E. Barrett and Frederick L. Pearce)
- 1) Introduction
- ・Definitions and Nomenclature
- 2) Mast Cell Growth and Differentiation
- ・Mast Cell Precursors
- ・Mast Cell Growth Factors
- ・Routre to Mast Cell Subpopulations
- 3) Expression of Mast Cell Heterogeneity
- ・Histochemical Characteristics
- ・Mediators
- ・Functional Aspects
- 4) Implications of Mast Cell Heterogeneity
- 5) Acknowledgements
- 6) References
- 4."The High-Affinity IgE Receptor"(Gottfried Alber and Henry Metzger)
- 1) Introduction
- 2) The Genes for the Subunits
- ・Chromosomal Localization
- ・Genomic Organization
- 3) Receptor Expression
- ・Developmental Aspects
- ・Biosynthesis
- ・Expression of Transfected Receptors
- 4) Structure of the Receptor
- ・Individual Subunits
- ・Comparison with Other Fc Receptors
- 5) Srtucture-Function Relationships
- ・Interaction with IgE
- ・Receptor Activation
- 6) Concluding Remarks
- 7) References
- 5. "Non-immunological Stimuli of Mast Cells and Basophil Leucocytes"(John C. Foreman)
- 1) Introduction
- 2) Peptides and Polybasic Components
- ・Compound 48/80
- ・Peptides from the CH4 Domain of IgE
- ・Neuropeptides
- ・Other Peptides
- 3) Anaphylatoxins
- 4) Interleukins
- 5) Dextran
- 6) Lectins
- 7) Probes of Signal Transducers
- 8) References
- 6. "Signal-Transmission Pathways in Mast Cell Exocytosis"(Ronit Sagi-Eisenberg)
- 1) Mast Cells as a Model System for the Study of Exocytosis
- 2) Mast Cell Secretagogues
- 3) Mast Cell Activation
- ・Role of Phosphatidylinositol (P1) Hydrolysis in Exocytosis
- 7. "Ultrastructural Analysis of Anaphylactic and Piecemeal Degranulation
of Human Mast Cells and Basophils"(Ann M. Dvorak)
- 1) Introduction
- 2) HUman Basophils
- ・General Ultrastructural Anatomy
- ・Piecemeal Degranulation
- ・Anaphylactic Degranulation
- 3) Human Mast Cells
- ・General Ultrastructural Anatomy
- ・Piecemeal Degranulation
- ・Anaphylactic Degranulation
- 4) Summary
- 5) Acknowledgements
- 6) References
- 8. "Mast Cell-Derived Mediators"(Rauno J. Harvima and Lawrence B. Schwartz)
- 1) Introduction
- 2) Mediators Derived from Mast Cells and Basophils
- ・Preformed Granule-associated Mediators
- ・Newly Generated Lipid Mediator Synthesized from Arachidomic Acid
- ・Cytokines
- 3) Mediators as Clinical Indicators of Mast Cell and Basophil Involvement in Disease
- 4) References
- 9. "Drugs Modifying the Responses of Mast Cells and Basophils"
(Yoshimichi Okayama and Martin K. Church)
- 1) Introduction
- 2) Dispersal and Purification of Mast Cells and Assessment of Mediator Release
- 3) Sodium Cromoglycate and Nedocromil Sodium
- ・Possible Mechanisms of Action of SCG and Nedocromil
- 4) β-Adreoceptor Agonists
- 5) Methylxanithines
- 6) Antihistamines
- 7) Conclusion
- 8) References
- 10. "Cutaneous Basophil Hypersensitivity - A Twenty-Year Perspective, 1970 to 1990"
(Ann M. Dvorak and Harold F. Dvorak)
- 1) Introduction
- 2) Historicak Perspective
- 3) Difference between Cutaneous Basophil Hypersensitivity
and Delayed Hypersensitivity
- 4) Basophil Tissue Infiltration in Multiple Species, Organs, Diseases and Circumstances
- 5) Lack of Specificity of the Majority of Basophils in CBH for Sensitizing Antigen
- 6) Regular Passive Transfer of CBH by Appropriately Sensitized Lymph Node Cells
- 7) Important Interactions between Basophils and Lymphocytes in CGH
- ・Induction of CGH
- ・Cytokins that Affect Basophil Function
- 8) Criteria for Morphological Identification of Basophils
in Multiple Mammalian Species
- 9) PMD is a Basophil Release Reaction Uniquely Present
in CGH and Tissue Basophils in View
- 10) Summary
- 11) Acknowledgements
- 12) References
- 11. "Mast Cells and the Lung"(C. P. Page and E. Minshall)
- 1) Introduction
- 2) Evidence for Mast Cell Activation in Asthma
- 3) Histamine
- 4) Prostaglation D2
- 5) Lipoxygenase Metabolites of Arachidonic Acid Metabolism
- 6) Platelet Activating Factor
- 7) Proteoglycans
- 8) Neutral Proteases
- 9) Cytokins
- 10) Mast Cell Involvement in Asthma
- 11) References
- 12. "Mast Cells in the Gastrointestinal Tract"(H. R. P. Miller)
- 1) Introduction and Historical Perspective
- 2) Mast Cell Heterogeneity
- ・Biochemistry and Histochemistry of Granule Glycosaminoglycans
- ・Heterogeneity of Granule Protease Expression
- ・Heterogeneity amongst Isolated Intestinal Mast Cell Subpopulations
- : Comparison with BMMCs
- 3) Signals that Recruit INtestinal Mast Cells
- ・In View Analysis
- ・In View Characterization of Factors Controlling Mast Cell Growth
- 4) Physiological Role of Gastrointestinal Mast Cells
- 5) Gastrointestinal Mast Cells in Disease
- ・Helminthiasis
- ・Enteric and Syntemic Anaphylaxis
- ・Clinical Disease of the GI Tract
- 6) Conclusions
- 7) References